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Chlorodifluoroacetic acid 99%min
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Chlorodifluoroacetic acid
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76-04-0 Usage

Chemical Properties

CLEAR COLORLESS TO PALE BROWN LIQUID AFTER MELTING
InChI:InChI=1/C2HClF2O2/c3-2(4,5)1(6)7/h(H,6,7)/p-1

76-04-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (C34200)  Chlorodifluoroaceticacid  98% 76-04-0 C34200-100G 740.61CNY Detail
Aldrich (C34200)  Chlorodifluoroaceticacid  98% 76-04-0 C34200-25G 352.17CNY Detail
TCI America (C0990)  Chlorodifluoroacetic Acid  >98.0%(T) 76-04-0 500g 2,690.00CNY Detail
TCI America (C0990)  Chlorodifluoroacetic Acid  >98.0%(T) 76-04-0 25g 225.00CNY Detail

76-04-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Chlorodifluoroacetic acid

1.2 Other means of identification

Product number -
Other names Acetic acid, chlorodifluoro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76-04-0 SDS

76-04-0Synthetic route

ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

carbon monoxide
201230-82-2

carbon monoxide

B

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With oxygen; chlorine at 24.84℃; under 760.051 Torr; Kinetics; Temperature; Irradiation;A 34%
B 88%
1,1-difluorotetrachloroethane
76-11-9

1,1-difluorotetrachloroethane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 30℃; for 4h;66.5%
ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ethanol; zinc for 1 - 3h; Product distribution / selectivity; Heating / reflux;A 9.7%
B 61.6%
C 0.4%
1,1,2-Trichloro-1,2,2-trifluoroethane
76-13-1

1,1,2-Trichloro-1,2,2-trifluoroethane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 20℃; for 10h;55.6%
sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate
89740-32-9

sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate

allyl bromide
106-95-6

allyl bromide

A

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane
354-53-0

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane

B

5-chloro-4,4,5,5-tetrafluoro-1-pentene
103780-92-3

5-chloro-4,4,5,5-tetrafluoro-1-pentene

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate In N,N-dimethyl-formamide at 40℃; for 4h;A 22%
B 53%
C 14%
metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

A

carbon monoxide
201230-82-2

carbon monoxide

B

formic difluorochloroacetic anhydride

formic difluorochloroacetic anhydride

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With oxygen; chlorine at 24.84℃; under 760.051 Torr; Kinetics; Temperature; Irradiation;A 26%
B n/a
C 34%
sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate
89740-32-9

sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate

propargyl bromide
106-96-7

propargyl bromide

A

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane
354-53-0

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane

B

5-chloro-4,4,5,5-tetrafluoro-1,2-pentadiene
132673-96-2

5-chloro-4,4,5,5-tetrafluoro-1,2-pentadiene

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate In N,N-dimethyl-formamide at 40℃; for 4h;A 30%
B 32%
C 12%
methanol
67-56-1

methanol

chlordifluoroacetyl chloride
354-24-5

chlordifluoroacetyl chloride

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

difluoroacetic acid methyl ester
433-53-4

difluoroacetic acid methyl ester

C

metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

D

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With zinc at 20℃; for 1 - 3h; Product distribution / selectivity; Heating / reflux;A 2.6%
B 16.7%
C 0%
D 28.6%
metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

difluoroacetic acid methyl ester
433-53-4

difluoroacetic acid methyl ester

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With methanol; zinc at 50℃; for 1 - 4h; Product distribution / selectivity; Heating / reflux;A 0.3%
B 26.8%
C 0%
Difluoroacetic acid
381-73-7

Difluoroacetic acid

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With chlorine im direkten Sonnenlicht;
1,1,3-trichloro-1,3,3-trifluoroacetone
79-52-7

1,1,3-trichloro-1,3,3-trifluoroacetone

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkali hydroxide; benzene
With alkaline solution; benzene
With ammonium hydroxide
chlorodifluoroacetyl fluoride
354-27-8

chlorodifluoroacetyl fluoride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water
1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one
758-41-8

1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkali hydroxide; benzene
With alkaline solution; benzene
With ammonium hydroxide
1,3-dichloro-1,1,3,3-tetrafluoro-propan-2-one
127-21-9

1,3-dichloro-1,1,3,3-tetrafluoro-propan-2-one

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkali hydroxide; benzene
With alkaline solution; benzene
3.3.-difluoro-1.1.2.3-tetrachloro-propene-(1)

3.3.-difluoro-1.1.2.3-tetrachloro-propene-(1)

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkaline KMNO4 at 70℃;
With alkaline KMNO4 at 70℃;
difluorochloroacetyl chloride

difluorochloroacetyl chloride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water
1,1,3-trichloro-1,3,3-trifluoroacetone
79-52-7

1,1,3-trichloro-1,3,3-trifluoroacetone

benzene
71-43-2

benzene

potassium hydroxide

potassium hydroxide

A

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

B

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one
758-41-8

1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one

aqueous NaOH-solution

aqueous NaOH-solution

A

chloroform
67-66-3

chloroform

B

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

trichlorofluoromethane
75-69-4

trichlorofluoromethane

ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

1,1,3-trichloro-2-ethoxy-1,3,3-trifluoro-propan-2-ol

1,1,3-trichloro-2-ethoxy-1,3,3-trifluoro-propan-2-ol

B

1,3-dichloro-1,3,3-trifluoroacetone
56753-83-4

1,3-dichloro-1,3,3-trifluoroacetone

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: trichlorofluoromethane; ethyl 2-chloro-2,2-difluoroacetate With aluminium; mercury dichloride In N,N-dimethyl-formamide
Stage #2: With hydrogenchloride In N,N-dimethyl-formamide Title compound not separated from byproducts;
2-chloro-2,2-difluoronitroethane

2-chloro-2,2-difluoronitroethane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With sulfuric acid
chlorodifluoroacetic anhydride (ClF2CO)2O

chlorodifluoroacetic anhydride (ClF2CO)2O

2-chlorodifluoroethyl-4,5-dicyanoimidazol3

2-chlorodifluoroethyl-4,5-dicyanoimidazol3

aminosulfonic acid
5329-14-6

aminosulfonic acid

diaminomaleonitrile
1187-42-4

diaminomaleonitrile

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With sodium carbonate In diethylene glycol dimethyl ether; water
chlorodifluoroselenoacetic acid

chlorodifluoroselenoacetic acid

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water
chlordifluoroacetyl chloride
354-24-5

chlordifluoroacetyl chloride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water at 20 - 100℃;
p-cresol
106-44-5

p-cresol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

difluoro-(4-methylphenoxy)acetic acid
207803-79-0

difluoro-(4-methylphenoxy)acetic acid

Conditions
ConditionsYield
With sodium hydride In 1,4-dioxane for 3h; Heating;100%
pent-1-yn-5-ol
5390-04-5

pent-1-yn-5-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C7H7ClF2O2

C7H7ClF2O2

Conditions
ConditionsYield
With sulfuric acid In toluene at 110℃; for 10h;98.3%
5-Hexen-1-ol
821-41-0

5-Hexen-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroacetic acid allylhexyl ester

2-chloro-2,2-difluoroacetic acid allylhexyl ester

Conditions
ConditionsYield
With dodecatungstosilic acid In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 5h;98.2%
5-hexyl-1-ol
928-90-5

5-hexyl-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C8H9ClF2O2

C8H9ClF2O2

Conditions
ConditionsYield
With sulfuric acid In toluene at 110℃; for 10h;98.1%
homoalylic alcohol
627-27-0

homoalylic alcohol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroethylene butyl acetate
881903-10-2

2-chloro-2,2-difluoroethylene butyl acetate

Conditions
ConditionsYield
With dodecatungstosilic acid In toluene at 110℃; for 10h;97.8%
With toluene-4-sulfonic acid In hexane for 3h; Heating / reflux;85%
n-Pent-4-enyl alcohol
821-09-0

n-Pent-4-enyl alcohol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroacetate allyl pentyl ester

2-chloro-2,2-difluoroacetate allyl pentyl ester

Conditions
ConditionsYield
With phosphotungstic acid In toluene at 100℃; for 10h; Temperature; Solvent;97.6%
propargyl alcohol
107-19-7

propargyl alcohol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

propargyl 2-chloro-2,2-difluoroacetate
118373-19-6

propargyl 2-chloro-2,2-difluoroacetate

Conditions
ConditionsYield
With sulfuric acid; toluene-4-sulfonic acid In cyclohexane at 60℃; for 15h;97.6%
α-naphthol
90-15-3

α-naphthol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2,2-difluoro-2-(naphthalen-1-yloxy)acetic acid

2,2-difluoro-2-(naphthalen-1-yloxy)acetic acid

Conditions
ConditionsYield
Stage #1: α-naphthol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
97%
(Z)-4-benzyloxy-but-2-en-1-ol
81028-03-7

(Z)-4-benzyloxy-but-2-en-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

chlorodifluoroacetic acid (Z)-5-benzyloxy-pent-2-enyl ester
807378-02-5

chlorodifluoroacetic acid (Z)-5-benzyloxy-pent-2-enyl ester

Conditions
ConditionsYield
With sulfuric acid In toluene for 7h; Heating;96%
4-methoxy-phenol
150-76-5

4-methoxy-phenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2,2-difluoro-2-(4-methoxyphenoxy)acetic acid

2,2-difluoro-2-(4-methoxyphenoxy)acetic acid

Conditions
ConditionsYield
Stage #1: 4-methoxy-phenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
96%
4-Phenylphenol
92-69-3

4-Phenylphenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-([1,1'-biphenyl]-4-yloxy)-2,2-difluoroacetic acid

2-([1,1'-biphenyl]-4-yloxy)-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: 4-Phenylphenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
96%
2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

trifluoroacetic acid
76-05-1

trifluoroacetic acid

Conditions
ConditionsYield
With potassium fluoride In water at 140℃; for 1h;95%
(+/-)-1-trimethylsilyl-1-pentyn-3-ol
18269-90-4

(+/-)-1-trimethylsilyl-1-pentyn-3-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C10H15ClF2O2Si

C10H15ClF2O2Si

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;95%
N-methylcarbazole
1484-12-4

N-methylcarbazole

chlorodifluoroacetic anhydride
2834-23-3

chlorodifluoroacetic anhydride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C15H10Cl2FNO

C15H10Cl2FNO

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;95%
chlorodifluoroacetic anhydride
2834-23-3

chlorodifluoroacetic anhydride

3,6,9-trimethyl-9H-carbazole
66294-86-8

3,6,9-trimethyl-9H-carbazole

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C17H14Cl2FNO

C17H14Cl2FNO

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;94%
p-Chlorothiophenol
106-54-7

p-Chlorothiophenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid
16503-81-4

2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: p-Chlorothiophenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
92%
1-butyn-4-ol
927-74-2

1-butyn-4-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C6H5ClF2O2

C6H5ClF2O2

Conditions
ConditionsYield
With phosphoric acid; sulfuric acid In toluene at 110℃; for 10h;90.2%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

1-chloro-1,1-difluoroacetone monohydrate
88257-33-4

1-chloro-1,1-difluoroacetone monohydrate

Conditions
ConditionsYield
In diethyl ether at 10℃; for 0.5h;90%
In diethyl ether
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

α,α-difluoro(4-fluorophenylthio)acetic acid
911360-86-6

α,α-difluoro(4-fluorophenylthio)acetic acid

Conditions
ConditionsYield
Stage #1: 4-Fluorothiophenol; 2-chloro-2,2-difluoroacetic acid With sodium hydride In 1,4-dioxane at 0 - 100℃; for 3h;
Stage #2: With hydrogenchloride In 1,4-dioxane; ethanol; water at 0℃;
90%
C21H24O4

C21H24O4

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C21H21ClF2O4

C21H21ClF2O4

Conditions
ConditionsYield
Stage #1: C21H24O4 With diisobutylaluminium hydride In dichloromethane at -78℃;
Stage #2: 2-chloro-2,2-difluoroacetic acid In dichloromethane; chloroform Reflux;
90%
para-bromobenzenethiol
106-53-6

para-bromobenzenethiol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

α,α-difluoro(4-bromophenylthio)acetic acid

α,α-difluoro(4-bromophenylthio)acetic acid

Conditions
ConditionsYield
Stage #1: para-bromobenzenethiol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
90%
5-methoxy-N-methylindole
2521-13-3

5-methoxy-N-methylindole

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoro-1-(5-methoxy-1-methyl-1H-indol-3-yl)-ethan-1-one
1620097-97-3

2-chloro-2,2-difluoro-1-(5-methoxy-1-methyl-1H-indol-3-yl)-ethan-1-one

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation;89%
2.6-dimethylphenol
576-26-1

2.6-dimethylphenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-(2,6-dimethylphenoxy)-2,2-difluoroacetic acid

2-(2,6-dimethylphenoxy)-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: 2.6-dimethylphenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
89%
thiophenol
108-98-5

thiophenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2,2-difluoro-2-(phenylthio)acetic acid
46207-56-1

2,2-difluoro-2-(phenylthio)acetic acid

Conditions
ConditionsYield
Stage #1: thiophenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
88%
n-hexylmagnesium bromide
3761-92-0

n-hexylmagnesium bromide

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Chlorodifluoromethyl n-hexyl ketone
86340-68-3

Chlorodifluoromethyl n-hexyl ketone

Conditions
ConditionsYield
In diethyl ether at -20℃; for 12h;87%
In diethyl ether at -78 - 0℃;
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroacetophenone
384-67-8

2-chloro-2,2-difluoroacetophenone

Conditions
ConditionsYield
With sodium hydroxide87%
(S,E)-4,5-bis(benzyloxy)pent-2-en-1-ol
1001273-06-8

(S,E)-4,5-bis(benzyloxy)pent-2-en-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

(S,E)-4,5-bis(benzyloxy)pent-2-enyl 2-chloro-2,2-difluoroacetate
1001273-08-0

(S,E)-4,5-bis(benzyloxy)pent-2-enyl 2-chloro-2,2-difluoroacetate

Conditions
ConditionsYield
In chloroform for 10h; Heating;87%
1,6-dimethyl-1H-indole
5621-15-8

1,6-dimethyl-1H-indole

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-1-(1,6-dimethyl-1H-indol-3-yl)-2,2-difluoroethan-1-one

2-chloro-1-(1,6-dimethyl-1H-indol-3-yl)-2,2-difluoroethan-1-one

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation;87%
triethylsilane
617-86-7

triethylsilane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C14H31ClF2O2Si2

C14H31ClF2O2Si2

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate In dichloromethane at 23℃; for 1h;87%

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