1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A

Base Information

Chemical Name:1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A
CAS No.:129254-37-1
Molecular Formula:C₂₅H₂₇N₃O₉S
Molecular Weight:545.57
Hs Code.:

Synonyms:1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A

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Chemical Property of 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A

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Technology Process of 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A

There total 3 articles about 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1950-65-8
4-methoxybenzenesulfenyl chloride

: 122644-75-1
6-Demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-methylidenemitosane

: 129254-37-1
1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A

Guidance literature:: With diethylamine; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jo00084a028

Reference yield:

: 696-63-9
4-Methoxybenzenethiol

: 129254-37-1
1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A

Guidance literature:: Multi-step reaction with 2 steps

1: NCS

2: 36 percent / Et₂NH / CH₂Cl₂ / 5 h / Ambient temperature

With N-chloro-succinimide; diethylamine; In dichloromethane;
DOI:10.1021/jo00084a028

Reference yield:

: 122644-74-0,122675-60-9,134679-23-5
1a-acetyl-7-demethoxy-6,7-dihydro-7,7-(ethylenedioxy)-6-(phenylselenyl)mitomycin A

: 129254-37-1
1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃, m-CPBA / CH₂Cl₂ / 1.) -40 to -20 deg C, 1 h, 2.) 20 deg C, 90 min

2: 36 percent / Et₂NH / CH₂Cl₂ / 5 h / Ambient temperature

With potassium carbonate; diethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jo00084a028