(4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol

Base Information

• Chemical Name: (4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol
• CAS No.: 782450-49-1
• Molecular Formula: C₁₃H₁₆N₄O₃
• Molecular Weight: 276.295
• Mol file: 782450-49-1.mol

Synonyms:(4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol

Chemical Property of (4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol

There total 1 articles about (4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4-ethynylphenyl)methanol (10602-04-7) + (3S,4R)-4-Azido-tetrahydro-furan-3-ol (153610-13-0) → (4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol (782450-49-1)

Guidance literature:

(4-ethynylphenyl)methanol; With polystyrene-bound N-hydroxyphthalimide resin; tributylphosphine; diamide; In tetrahydrofuran; dichloromethane; at 20 ℃;

(3S,4R)-4-Azido-tetrahydro-furan-3-ol; With 2,6-dimethylpyridine; tetrakis(actonitrile)copper(I) hexafluorophosphate; In dichloromethane; at 20 ℃;

With hydrazine; In dichloromethane;

DOI:10.1016/j.tet.2004.05.109

Reference yield: 86.0%

(4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol (782450-49-1) + Estrone (53-16-7) → 3-hydroxylestra-1,3,5(10)-triene-17-one O-{4-[1-[(4R)-hydroxy-tetrahydro-furan-(3R)-yl]-1H-[1,2,3]-triazol-4-yl]-benzyl}-oxime

Guidance literature:

(4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol; Estrone; With acetic acid; ethyl acetate; at 150 ℃; for 0.5h; microwave irradiation;

With PL-MIA resin; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2004.05.109

Reference yield:

(4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol (782450-49-1) + (R)-2,3-cyclohexylideneglyceraldehyde (78008-36-3) → (Z)-1,4-dioxa-spiro[4.5]decane-2-carbaldehyde O-{4-[1-[(4R)-hydroxy-tetrahydro-furan-(3R)-yl]-1H-[1,2,3]triazol-4-yl]-benzyl}-oxime + (E)-1,4-dioxa-spiro[4.5]decane-2-carbaldehyde O-{4-[1-[(4R)-hydroxy-tetrahydro-furan-(3R)-yl]-1H-[1,2,3]triazol-4-yl]-benzyl}-oxime

Guidance literature:

(4R)-[4-(4-aminooxymethyl-phenyl)-[1,2,3]triazol-1-yl]-tetrahydro-furan-(3S)-ol; (R)-2,3-cyclohexylideneglyceraldehyde; In 1,2-dichloro-ethane; at 120 ℃; for 0.25h; microwave irradiation;

With PL-MIA resin; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2004.05.109

upstream raw materials:

(4-ethynylphenyl)methanol

(3S,4R)-4-Azido-tetrahydro-furan-3-ol