1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one

Base Information

Chemical Name:1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one
CAS No.:871693-04-8
Molecular Formula:C₂₆H₃₆O₅Si
Molecular Weight:456.654
Hs Code.:

Synonyms:1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one

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Chemical Property of 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one

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Technology Process of 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one

There total 5 articles about 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871693-03-7
1-hydroxy-1-[2-hydroxy-4-(4-methoxy-benzyloxy)-phenyl]-4-methyl-pent-1-en-3-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 871693-04-8
1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one

: C₂₆H₃₆O₅Si

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 60h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 871693-04-8
1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one

: C₂₆H₃₆O₅Si

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetone / 4 h / Heating / reflux

2.1: triethylamine / dmap / dichloromethane / 0 °C

2.2: 20 °C

3.1: sodium hydride / tetrahydrofuran / 2.25 h / 20 - 40 °C

4.1: 1H-imidazole / dmap / DMF (N,N-dimethyl-formamide) / 60 h / 20 °C

With 1H-imidazole; sodium hydride; potassium carbonate; triethylamine; potassium iodide; dmap; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; acetone;

Reference yield:

: 503469-24-7
4-(4-methoxybenzyloxy)-2-hydroxyacetophenone

: 871693-04-8
1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-phenyl]-1-hydroxy-4-methy1-pent-1-en-3-one

: C₂₆H₃₆O₅Si

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dmap / dichloromethane / 0 °C

1.2: 20 °C

2.1: sodium hydride / tetrahydrofuran / 2.25 h / 20 - 40 °C

3.1: 1H-imidazole / dmap / DMF (N,N-dimethyl-formamide) / 60 h / 20 °C

With 1H-imidazole; sodium hydride; triethylamine; dmap; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane;