5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide

Base Information

Chemical Name:5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide
CAS No.:1421318-23-1
Molecular Formula:C₄₅H₃₆N₈O₇S
Molecular Weight:832.896
Hs Code.:

Synonyms:5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide

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Chemical Property of 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide

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Technology Process of 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide

There total 12 articles about 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 138-39-6
4-homosulfanilamide

: 1421318-30-0
C₃₈H₂₈N₆O₆

: 1421318-23-1
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃; for 48h;
DOI:10.1039/c3cc38251f

Reference yield:

: 6427-66-3
4-azidobenzoic acid

: 1421318-23-1
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / Reflux

2.1: sodium hydroxide / methanol / 3 h / 50 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.08 h

3.2: 48 h / 40 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 h

6.1: sodium hydroxide / methanol / 6 h / 50 °C

7.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 40 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc38251f

Reference yield:

: 1421318-26-4
5-(4-azidobenzoylamino)isophthalic acid dimethyl ester

: 1421318-23-1
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}-N'-(4-sulfamoylbenzyl)isophthalamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / methanol / 3 h / 50 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.08 h

2.2: 48 h / 40 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 h

5.1: sodium hydroxide / methanol / 6 h / 50 °C

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 40 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc38251f