5-methyl-4-phenyl-1-(3-propylthio)imidazole

Base Information

• Chemical Name: 5-methyl-4-phenyl-1-(3-propylthio)imidazole
• CAS No.: 141816-06-0
• Molecular Formula: C₁₃H₁₆N₂S
• Molecular Weight: 232.349
• Mol file: 141816-06-0.mol

Synonyms:5-methyl-4-phenyl-1-(3-propylthio)imidazole

Chemical Property of 5-methyl-4-phenyl-1-(3-propylthio)imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-4-phenyl-1-(3-propylthio)imidazole

There total 3 articles about 5-methyl-4-phenyl-1-(3-propylthio)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-4-phenyl-1-(3-thiobenzoylpropyl)imidazole (1026084-43-4) → 5-methyl-4-phenyl-1-(3-propylthio)imidazole (141816-06-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h;

DOI:10.1021/jm00063a013

Reference yield:

4(5)-phenyl-5(4)-methylimidazole (826-83-5) → 5-methyl-4-phenyl-1-(3-propylthio)imidazole (141816-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 60 deg C, 3 h

2: 68 percent / dimethylformamide / 1 h / 60 °C

3: LiAlH₄ / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00063a013

Reference yield:

1-(3-chloropropyl)-5-methyl-4-phenylimidazole (141815-91-0) → 5-methyl-4-phenyl-1-(3-propylthio)imidazole (141816-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / dimethylformamide / 1 h / 60 °C

2: LiAlH₄ / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00063a013

upstream raw materials:

5-methyl-4-phenyl-1-(3-thiobenzoylpropyl)imidazole

4(5)-phenyl-5(4)-methylimidazole

1-(3-chloropropyl)-5-methyl-4-phenylimidazole

Downstream raw materials:

3-<<3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propyl>thio>-2-nitrotoluene

2-methyl-6-<<3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propyl>thio>aniline

N-[6-methyl-2-{3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propylthio}]-phenyl-N'-pentylurea

Refernces