arabino-Hexitol,3,6-anhydro-1,2-dideoxy-2-methyl-4-O-methyl-(9CI)

Base Information

Chemical Name:arabino-Hexitol,3,6-anhydro-1,2-dideoxy-2-methyl-4-O-methyl-(9CI)
CAS No.:200347-38-2
Molecular Formula:C₈H₁₆O₃
Molecular Weight:160.213
Hs Code.:
Mol file:200347-38-2.mol

Synonyms:arabino-Hexitol,3,6-anhydro-1,2-dideoxy-2-methyl-4-O-methyl-(9CI)

Suppliers and Price of arabino-Hexitol,3,6-anhydro-1,2-dideoxy-2-methyl-4-O-methyl-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of arabino-Hexitol,3,6-anhydro-1,2-dideoxy-2-methyl-4-O-methyl-(9CI)

Chemical Property:

Boiling Point:241.0±40.0 °C(Predicted)
PKA:13.82±0.60(Predicted)
PSA：0.00000
Density:1.03±0.1 g/cm3(Predicted)
LogP:0.00000

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of arabino-Hexitol,3,6-anhydro-1,2-dideoxy-2-methyl-4-O-methyl-(9CI)

There total 6 articles about arabino-Hexitol,3,6-anhydro-1,2-dideoxy-2-methyl-4-O-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 200347-37-1
(4S,5R)-5-Isopropyl-4-methoxy-dihydro-furan-3-one

: 200347-38-2
(3R,4R,5R)-5-Isopropyl-4-methoxy-tetrahydro-furan-3-ol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 ℃; for 0.416667h;
DOI:10.1016/S0040-4039(97)10294-5

Reference yield:

: 200347-21-3
1-methoxy-3-methyl-1-(phenylthio)-2-butanol

: 200347-38-2
(3R,4R,5R)-5-Isopropyl-4-methoxy-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / Aliquat 336, 50percent aq NaOH / CH₂Cl₂ / 3.3 h / Ambient temperature

2: 95 percent / KHMDS / tetrahydrofuran / 0.75 h

3: 22 percent Spectr_. / dimethyl(thiomethyl)sulfonium tetrafluoroborate, DBU / CH₂Cl₂

4: 84 percent / KHMDS / toluene / 0.58 h

5: 67 percent / NaIO₄, RuCl₃*H₂O / CCl₄; acetonitrile; H₂O / 0.92 h / Ambient temperature

6: 36 percent / L-Selectride / tetrahydrofuran / 0.42 h / -78 °C

With ruthenium trichloride; sodium hydroxide; sodium periodate; dimethyl(methylthio)sulfonium tetrafluoroborate; potassium hexamethylsilazane; L-Selectride; Aliquat 336; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(97)10294-5

Reference yield:

: tert-Butyl-{1-[(4S,5S)-5-isopropyl-4-methoxy-dihydro-furan-(3E)-ylidene]-2,2-dimethyl-propoxy}-dimethyl-silane

: 200347-38-2
(3R,4R,5R)-5-Isopropyl-4-methoxy-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / NaIO₄, RuCl₃*H₂O / CCl₄; acetonitrile; H₂O / 0.92 h / Ambient temperature

2: 36 percent / L-Selectride / tetrahydrofuran / 0.42 h / -78 °C

With ruthenium trichloride; sodium periodate; L-Selectride; In tetrahydrofuran; tetrachloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(97)10294-5