1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one

Base Information

• Chemical Name: 1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one
• CAS No.: 200347-25-7
• Molecular Formula: C₁₉H₃₀O₃S
• Molecular Weight: 338.511
• Mol file: 200347-25-7.mol

Synonyms:1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one

Chemical Property of 1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one

There total 2 articles about 1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(4,4-dimethyl-3-oxo-pentyl)-trimethyl-ammonium; iodide (60676-26-8) + 1-methoxy-3-methyl-1-(phenylthio)-2-butanol (200347-21-3) → 1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one (200347-25-7)

Guidance literature:

With sodium hydroxide; Aliquat 336; In dichloromethane; for 3.3h; Ambient temperature;

DOI:10.1016/S0040-4039(97)10294-5

Reference yield:

methoxymethyl phenyl sulfide (13865-50-4) → 1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one (200347-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / t-BuLi / tetrahydrofuran / -78 °C

2: 67 percent / Aliquat 336, 50percent aq NaOH / CH₂Cl₂ / 3.3 h / Ambient temperature

With sodium hydroxide; tert.-butyl lithium; Aliquat 336; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(97)10294-5

Reference yield: 95.0%

t-butyldimethylsiyl triflate (69739-34-0) + 1-[1-(Methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-4,4-dimethyl-pentan-3-one (200347-25-7) → tert-Butyl-{(Z)-1-tert-butyl-3-[1-(methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-propenyloxy}-dimethyl-silane (200347-29-1)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; for 0.75h;

DOI:10.1016/S0040-4039(97)10294-5

upstream raw materials:

(4,4-dimethyl-3-oxo-pentyl)-trimethyl-ammonium; iodide

1-methoxy-3-methyl-1-(phenylthio)-2-butanol

methoxymethyl phenyl sulfide

Downstream raw materials:

tert-Butyl-{(Z)-1-tert-butyl-3-[1-(methoxy-phenylsulfanyl-methyl)-2-methyl-propoxy]-propenyloxy}-dimethyl-silane

(3R,4R,5R)-5-Isopropyl-4-methoxy-tetrahydro-furan-3-ol

(4S,5R)-5-Isopropyl-4-methoxy-dihydro-furan-3-one