N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

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Chemical Name:N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide
CAS No.:1372262-84-4
Molecular Formula:C₂₆H₃₂N₈O₄S
Molecular Weight:552.657
Hs Code.:

Synonyms:N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

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Chemical Property of N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

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Technology Process of N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

There total 14 articles about N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372262-90-2
N-ethyl-N-(3-((2-(2-methoxy-4-morpholinophenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide

: 1372262-84-4
N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; ethylenediamine; In tetrahydrofuran; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1372262-84-4
N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2: tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

3: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16.08 h / 110 °C / Inert atmosphere

4: Oxone / water; tetrahydrofuran / 16.25 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 1.17 h / 170 °C / Microwave irradiation

6: ethylenediamine; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 80 °C / Inert atmosphere

With Oxone; tetrabutyl ammonium fluoride; sodium hydride; ethylenediamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 3939-13-7
3-cyano-2-fluoropyridine

: 1372262-84-4
N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 2.33 h / 20 °C / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: hydrogen; ammonia / Ra-Ni / water; methanol / 43 h / 20 °C / 3102.97 Torr

4: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 1.17 h / 170 °C / Microwave irradiation

5: ethylenediamine; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 80 °C / Inert atmosphere

With potassium tert-butylate; tetrabutyl ammonium fluoride; ammonia; hydrogen; potassium carbonate; ethylenediamine; N-ethyl-N,N-diisopropylamine; Ra-Ni; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;