3939-13-7

Basic information

• Product Name: 3-Cyano-2-fluoropyridine
• Synonyms: 3-CYANO-2-FLUOROPYRIDINE;2-FLUOROPYRIDINE-3-CARBONITRILE;2-FLUORO-3-PYRIDINECARBONITRILE;2-FLUORO-3-CYANOPYRIDINE;2-Fluoronicotinonitrile;3-Cyano-4-fluoropyridine;3-Fluoro-4-cyanopyridine;4-Fluoro-nicotinonitrile
• CAS NO: 3939-13-7
• Molecular Formula: C₆H₃FN₂
• Molecular Weight: 122.1
• EINECS: 2017-001-1
• Product Categories: Pyridine;Pyridines;pyridine series
• Mol File: 3939-13-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 27-30°C
• Boiling Point: 214.6 °C at 760 mmHg
• Flash Point: 98℃
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0.154mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.88±0.10(Predicted)
• BRN: 386567
• CAS DataBase Reference: 3-Cyano-2-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyano-2-fluoropyridine(3939-13-7)
• EPA Substance Registry System: 3-Cyano-2-fluoropyridine(3939-13-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-5-36/38-22
• Safety Statements: 26-36/37/39-36-24/25-23-3
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 3939-13-7(Hazardous Substances Data)

Usage

General Description

3-Cyano-2-fluoropyridine is a chemical compound with the molecular formula C6H3FN2. It is a pyridine derivative and a highly reactive compound due to the presence of the cyano and fluorine functional groups. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known for its versatile reactivity and is often used in organic synthesis to introduce the cyano and fluorine groups into larger molecules. 3-Cyano-2-fluoropyridine is also used in the production of insecticides and fungicides, as well as in the development of new materials in the pharmaceutical industry. Due to its potential toxicity and reactivity, it should be handled with caution and proper safety measures.

InChI:InChI=1/C6H3FN2/c7-6-5(4-8)2-1-3-9-6/h1-3H

Upstream product

• 364-22-7 2-fluoronicotinamide 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 100-54-9 pyridine-3-carbonitrile 
• 75-05-8 acetonitrile 
• 695-37-4 3-fluoropyridine-1-oxide 

Downstream Products

• 859850-79-6 C-(2-pyrrolidin-1-yl-pyridin-3-yl)-methylamine 
• 73161-37-2 N-(3-cyanopyridin-2-yl)-N-methylmethanesulfonamide 
• 1372262-84-4 N-ethyl-N-{3-[( {2-[(2-methoxy-4-morpholin-4-ylphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide 
• 1372262-90-2 N-ethyl-N-(3-((2-(2-methoxy-4-morpholinophenylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide 
• 939791-42-1 N-(3-(aminomethyl)pyridine-2-yl)-N-methylmethanesulfonamide 
• 1227173-68-3 2-(4-(1-methyl-1H-benzo[d]imidazol-2-ylamino)phenoxy)nicotinonitrile 
• 61337-88-0 3-cyano-2-(4-methyl-2-phenyl-1-piperazynyl)pyridine 
• 945347-61-5 2-(2-methoxy-ethylamino)-nicotinonitrile 
• 205744-16-7 2-fluoro-3-(aminomethyl)pyridine 
• 59025-38-6 2-(pyrrolidin-1-yl)nicotinonitrile 

Relevant articles and documents

Diastereoselective Synthesis of Dialkylated Bis(phosphino)ferrocenes: Their Use in Promoting Silver-Mediated Nucleophilic Fluorination of Chloroquinolines

The diastereoselective synthesis of dialkylated ferrocenyl bis(phosphane)s bearing aryl, alkyl, and hetero- or polycyclic substituents on the phosphino groups is reported, together with their characterization in the solid state by X-ray structure analysis

PROCESS FOR FLUORINATING COMPOUNDS

Disclosed are mild temperature (e.g., from 0 to 80°C) SNAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMe4F.

Acyl azolium fluorides for room temperature nucleophilic aromatic fluorination of chloro- and nitroarenes

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.