(S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

Base Information

Chemical Name:(S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate
CAS No.:1352064-36-8
Molecular Formula:C₂₈H₃₃Cl₂N₅O₃
Molecular Weight:558.508
Hs Code.:

Synonyms:(S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

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Chemical Property of (S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

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Technology Process of (S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

There total 6 articles about (S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352076-02-8
(S)-tert-butyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-(cyanomethyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

: 1352064-36-8
(S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 90 ℃; for 120h;

Reference yield:

: 1352076-01-7
C₂₈H₃₄Cl₂N₂O₄

: 1352064-36-8
(S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 90 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm300354j

Reference yield:

: 102152-36-3,102152-37-4,24457-21-4
tert-butyl 2-bromobutyrate

: 1352064-36-8
(S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 25 °C / Inert atmosphere

2.1: sodium periodate; ruthenium(III) trichloride hydrate / tetrachloromethane; water; acetonitrile / 3 h / 25 °C / Inert atmosphere

3.1: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.1: ammonia / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

5.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C / Inert atmosphere

With 4-methyl-morpholine; sodium periodate; sodium azide; ruthenium(III) trichloride hydrate; ammonia; sodium hydride; ammonium chloride; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm300354j