1352076-01-7

Basic information

• Product Name: C₂₈H₃₄Cl₂N₂O₄
• CAS NO: 1352076-01-7
• Molecular Weight: 533.495
• Mol File: 1352076-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₄Cl₂N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₄Cl₂N₂O₄(1352076-01-7)
• EPA Substance Registry System: C₂₈H₃₄Cl₂N₂O₄(1352076-01-7)

Safety Data

• Hazardous Substances Data: 1352076-01-7(Hazardous Substances Data)

Upstream product

• 102152-36-3 tert-butyl 2-bromobutyrate 
• 1352072-12-8 (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methylpiperidin-2-one 
• 1352063-19-4 2-((3R,5R,6S)-1-((S)-1-(tert-butoxy)-1-oxo-butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid 
• 1375799-10-2 (S)-tert-butyl 2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate 

Downstream Products

• 1352064-36-8 (S)-tert-butyl 2-((3R,5R,6S)-3-((1H-tetrazol-5-yl)methyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanoate 

Relevant articles and documents

Structure-based design of novel inhibitors of the MDM2-p53 interaction

Structure-based rational design led to the discovery of novel inhibitors of the MDM2-p53 protein-protein interaction. The affinity of these compounds for MDM2 was improved through conformational control of both the piperidinone ring and the appended N-alkyl substituent. Optimization afforded 29 (AM-8553), a potent and selective MDM2 inhibitor with excellent pharmacokinetic properties and in vivo efficacy.