trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

Base Information

Chemical Name:trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine
CAS No.:124217-13-6
Molecular Formula:C₁₉H₂₇NO₂
Molecular Weight:301.429
Hs Code.:

Synonyms:trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

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Technology Process of trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

There total 8 articles about trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 124216-77-9
trans-octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

: 7051-34-5
cyclopropylcarbinyl bromide

: 124217-13-6
trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 1.5h; Heating;
DOI:10.1039/P19890001187

Reference yield:

: 73224-22-3
1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

: 124217-13-6
trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

Guidance literature:: Multi-step reaction with 8 steps

2: 1)(COCl)2, DMSO, 2) NEt₃ / 1) CH₂Cl₂, - 60 deg C, 15 min; 2) CH₂Cl₂, -20 deg C

3: 1) NaH / 1) DMF, r.t., 3 h, 2) DMF,r.t., 45 min

5: 1)CH₃SO₂Cl, Et₃N, 2) NaH / 1) CH₂Cl₂, -10 deg C, 0.5 h; 2) DMF, 70 deg C, 3 h

6: K₂CO₃ / 1,2-dichloro-ethane / 3.5 h / Heating

7: 2M HCL / methanol / 3.5 h / Heating

8: 72 percent / NaHCO₃ / dimethylformamide / 1.5 h / Heating

With hydrogenchloride; oxalyl dichloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/P19890001187

Reference yield:

: 124216-72-4
trans-4-(3-methoxyphenyl)-1-methylpiperidin-3-ol

: 124217-13-6
trans-7-(cyclopropylmethyl)octahydro-4a-(3-methoxyphenyl)-2H-pyrano<2,3-c>pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 1)(COCl)2, DMSO, 2) NEt₃ / 1) CH₂Cl₂, - 60 deg C, 15 min; 2) CH₂Cl₂, -20 deg C

2: 1) NaH / 1) DMF, r.t., 3 h, 2) DMF,r.t., 45 min

4: 1)CH₃SO₂Cl, Et₃N, 2) NaH / 1) CH₂Cl₂, -10 deg C, 0.5 h; 2) DMF, 70 deg C, 3 h

5: K₂CO₃ / 1,2-dichloro-ethane / 3.5 h / Heating

6: 2M HCL / methanol / 3.5 h / Heating

7: 72 percent / NaHCO₃ / dimethylformamide / 1.5 h / Heating

With hydrogenchloride; oxalyl dichloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/P19890001187