73224-22-3Relevant academic research and scientific papers
CYCLIC AMINO COMPOUND
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Paragraph 0096-0098, (2019/09/21)
PROBLEM TO BE SOLVED: To provide a novel compound that has excellent skin permeability with reduced skin irritation and is used for treating and/or preventing a pain. SOLUTION: The present invention provides a compound of formula (I) or a pharmaceutically
Synthesis of Picenadol via Metalloenamine Alkylation Methodology
Barnett, Charles J.,Copley-Merriman, Catherine R.,Maki, James
, p. 4795 - 4800 (2007/10/02)
A convenient synthesis of the novel phenylpiperidine analgesic agent picenadol, (+/-)-1, via tetrahydropyridine 2 is described.Tetrahydropyridine 7, prepared from 6 via metalation (n-butyllithium) and alkylation with 1-bromopropane, could not be directly
4a-Aryl-octahydro-1H-2-pyrindines
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, (2008/06/13)
4a-phenyl and substituted phenyl 2,3,4,4a,5,6,7,7a-octahydro-1H-2-pyrindines having a 2-substituent are disclosed. Such compounds are useful as analgesic agents having mixed agonist and antagonist properties. The compounds can be prepared by reacting an a
Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
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, (2008/06/13)
4a-Arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroquinolines analgesic agonists and antagonists are prepared doubly alkylating a 4-aryltetrahydropyridine with an α,ω-dihaloalkane.
