(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

Base Information

Chemical Name:(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate
CAS No.:376608-67-2
Molecular Formula:C₁₉H₂₄F₂O₂
Molecular Weight:322.395
Hs Code.:

Synonyms:(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

Suppliers and Price of (E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

There total 5 articles about (E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 376608-66-1
(E)-3-(3,4-difluorophenyl)acryloyl chloride

: (-)-menthol

: 376608-67-2
(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

Guidance literature:: With pyridine; In toluene; at 60 ℃; for 2h; Inert atmosphere;

Reference yield: 53.0%

: 376608-66-1
(E)-3-(3,4-difluorophenyl)acryloyl chloride

: 2216-51-5
(-)-menthol

: 376608-67-2
(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

Guidance literature:: With pyridine; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jacs.8b05243

Reference yield:

: 112897-97-9
(E)-3-(3,4-difluorophenyl)acrylic acid

: 376608-67-2
(E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(3,4-difluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / 80 °C / Inert atmosphere

2: pyridine; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jacs.8b05243