3-(Pyrrolidin-1-yl)propanamide

Base Information

• Chemical Name: 3-(Pyrrolidin-1-yl)propanamide
• CAS No.: 24438-88-8
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.201
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00455298
• Nikkaji Number: J1.992.105K
• Wikidata: Q82277239
• ChEMBL ID: CHEMBL4564887
• Mol file: 24438-88-8.mol

Synonyms:3-(Pyrrolidin-1-yl)propanamide;24438-88-8;3-pyrrolidin-1-ylpropanamide;3-Pyrrolizinopropanamide;SCHEMBL1007439;CHEMBL4564887;DTXSID00455298;CGKYDLSLIFODDP-UHFFFAOYSA-N;AKOS005061450;CS-0306607;FT-0691170;EN300-304839

Chemical Property of 3-(Pyrrolidin-1-yl)propanamide

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.499
• Boiling Point: 309.698°C at 760 mmHg
• Flash Point: 141.101°C
• PSA: 46.33000
• Density: 1.056g/cm³
• LogP: 0.59580
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 142.110613074
• Heavy Atom Count: 10
• Complexity: 119

Purity/Quality:

98% ^*data from raw suppliers

3-(Pyrrolidin-1-yl)propanamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)CCC(=O)N

Technology Process of 3-(Pyrrolidin-1-yl)propanamide

There total 3 articles about 3-(Pyrrolidin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyrrolidine (123-75-1) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) → 3-(pyrrolidin-1-yl)propanamide (24438-88-8)

Guidance literature:

With Imidazole hydrochloride; In neat (no solvent); at 20 ℃; for 0.5h; Green chemistry;

DOI:10.3390/molecules24234224

Reference yield: 17.1%

pyrrolidine (123-75-1) + 3-bromopropanamide (6320-96-3) → 3-(pyrrolidin-1-yl)propanamide (24438-88-8)

Guidance literature:

In methanol; at 80 ℃;

Reference yield:

→ 3-(pyrrolidin-1-yl)propanamide (24438-88-8)

Guidance literature:

Aus 2,3,4,6,7,8-Hexahydro-pyrrolo-<1,2-a>-pyrimidin-2-on (7a) in A., Hydrieren an Platin;

upstream raw materials:

pyrrolidine

2-propenamide

3-bromopropanamide