2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile

Base Information

• Chemical Name: 2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile
• CAS No.: 152036-87-8
• Molecular Formula: C₁₇H₁₁BrN₂O
• Molecular Weight: 339.191
• Mol file: 152036-87-8.mol

Synonyms:2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile

Chemical Property of 2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile

There total 1 articles about 2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoquinoline (119-65-3) + trimethylsilyl cyanide (7677-24-9) + 4-chlorobenzoyl chloride (586-75-4) → 2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile (152036-87-8)

Guidance literature:

With aluminium trichloride; Yield given. Multistep reaction; 1) CH₂Cl₂, room temperature; 2) CH₂Cl₂, 30 deg C, 12 h;

Reference yield: 77.4%

2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile (152036-87-8) → C17H12BrN2O(1+)*BF4(1-)

Guidance literature:

With tetrafluoroboric acid; In acetic acid; at 75 ℃; for 0.0833333h;

Reference yield:

2-(4-Bromo-benzoyl)-1,2-dihydro-isoquinoline-1-carbonitrile (152036-87-8) + ethyl 2-((tert-butoxycarbonyloxy)(phenyl)methyl)acrylate → ethyl 2-((2-(4-bromobenzoyl)-1-cyano-1,2-dihydroisoquinolin-1-yl)(phenyl)methyl)acrylate (1422030-67-8) + ethyl 2-((2-(4-bromobenzoyl)-1-cyano-1,2-dihydroisoquinolin-1-yl)(phenyl)methyl)acrylate

Guidance literature:

With quinindine; In 5,5-dimethyl-1,3-cyclohexadiene; at 30 ℃; for 24h; Overall yield = 99 %; stereoselective reaction; Inert atmosphere;

DOI:10.1039/c2ob27269e

upstream raw materials:

isoquinoline

trimethylsilyl cyanide

4-chlorobenzoyl chloride

Downstream raw materials:

methyl 2-((2-(4-bromobenzoyl)-1-cyano-1,2-dihydroisoquinolin-1-yl)(phenyl)methyl)acrylate

ethyl 2-((2-(4-bromobenzoyl)-1-cyano-1,2-dihydroisoquinolin-1-yl)(phenyl)methyl)acrylate

tert-butyl 2-((2-(4-bromobenzoyl)-1-cyano-1,2-dihydroisoquinolin-1-yl)(phenyl)methyl)acrylate