sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

Base Information

Chemical Name:sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate
CAS No.:109553-28-8
Molecular Formula:C₂₀H₂₉F₂N₂O₅*Na
Molecular Weight:438.447
Hs Code.:

Synonyms:sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

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Chemical Property of sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

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Technology Process of sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

There total 4 articles about sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109553-27-7
4(S)-<1(S)-<(tert-butyloxycarbonyl)amino>-3-methylbutyl>-3,3-difluoro-1-(methoxyphenyl)-2-azetidinone

: 109553-28-8
sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 20h;
DOI:10.1021/jm00393a026

Reference yield:

: 104-94-9
4-methoxy-aniline

: 109553-28-8
sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / diisopropylethylamine, bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 15 h / Ambient temperature

2: 100 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

3: 1M aq. NaOH / tetrahydrofuran / 20 h

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00393a026

Reference yield:

: 109553-26-6
N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanamide

: 109553-28-8
sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

2: 1M aq. NaOH / tetrahydrofuran / 20 h

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jm00393a026