5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline

Base Information

Chemical Name:5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline
CAS No.:1374154-83-2
Molecular Formula:C₂₃H₂₀FNO₆S₂
Molecular Weight:489.545
Hs Code.:

Synonyms:5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline

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Chemical Property of 5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline

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Technology Process of 5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline

There total 2 articles about 5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63758-12-3
6-chlorosulfonyl-1,4-benzodioxane

: 875526-26-4
2-methyl-1-(methylsulfonyl)indoline

: 1374154-83-2
5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline

Guidance literature:: 6-chlorosulfonyl-1,4-benzodioxane; aluminum (III) chloride; In dichloromethane; for 0.166667h;

2-methyl-1-(methylsulfonyl)indoline; In dichloromethane; at 70 ℃; for 1h; Pressure ampoule;

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 6872-06-6
2-methyl indoline

: 1374154-83-2
5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1-((4-fluorophenyl)sulfonyl)-2-methylindoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 2 h / 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 0.17 h

2.2: 1 h / 70 °C / Pressure ampoule

With pyridine; aluminum (III) chloride; In dichloromethane; 2.2: Friedel Crafts Acylation;