(Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione

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Chemical Name:(Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione
CAS No.:1620146-62-4
Molecular Formula:C₂₄H₂₉NO₅S
Molecular Weight:443.564
Hs Code.:

Synonyms:(Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione

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Chemical Property of (Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione

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Technology Process of (Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione

There total 7 articles about (Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.1%

: 41004-19-7
1-iodo-3-methyl-but-2-ene

: 1620146-58-8
(Z)-5-(5-allyl-4-((tetrahydro-2H-pyran-2-yl)oxy)-2-methoxybenzylidene)thiazolidine-2,4-dione

: 1620146-62-4
(Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione

Guidance literature:: With potassium carbonate; In acetone; Reflux;
DOI:10.1016/j.bmcl.2014.05.099

Reference yield:

: 68287-22-9
4-(allyloxy)-2-hydroxybenzaldehyde

: 1620146-62-4
(Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 15 h / 20 °C

2: N,N-diethylaniline / 24 h / 200 °C / Inert atmosphere

3: pyridinium p-toluenesulfonate / dichloromethane / 20 °C / Inert atmosphere

4: piperdinium acetate / toluene / 8 h / Reflux

5: potassium carbonate / acetone / Reflux

With pyridinium p-toluenesulfonate; piperdinium acetate; potassium carbonate; N,N-diethylaniline; In dichloromethane; acetone; toluene; 2: |Claisen Rearrangement / 4: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2014.05.099

Reference yield:

: 813414-08-3
4-(allyloxy)-2-methoxybenzaldehyde

: 1620146-62-4
(Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-diethylaniline / 24 h / 200 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / dichloromethane / 20 °C / Inert atmosphere

3: piperdinium acetate / toluene / 8 h / Reflux

4: potassium carbonate / acetone / Reflux

With pyridinium p-toluenesulfonate; piperdinium acetate; potassium carbonate; N,N-diethylaniline; In dichloromethane; acetone; toluene; 1: |Claisen Rearrangement / 3: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2014.05.099