813414-08-3

Upstream product

• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 74-90-8 hydrogen cyanide 
• 37592-19-1 3-allyloxyanisole 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 68287-22-9 4-(allyloxy)-2-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 18278-34-7 4-hydroxy-2-methoxybenzaldehyde 
• 107-05-1 3-chloroprop-1-ene 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1220905-38-3 5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde 
• 1620146-58-8 (Z)-5-(5-allyl-4-((tetrahydro-2H-pyran-2-yl)oxy)-2-methoxybenzylidene)thiazolidine-2,4-dione 
• 1620146-59-9 (Z)-5-(5-allyl-4-((tetrahydro-2H-pyran-2-yl)oxy)-2-methoxybenzylidene)-3-methylthiazolidine-2,4-dione 
• 1620146-60-2 (Z)-5-(5-allyl-4-((tetrahydro-2H-pyran-2-yl)oxy)-2-methoxybenzylidene)-3-isopropylthiazolidine-2,4-dione 
• 1620146-61-3 (Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-allylthiazolidine-2,4-dione 
• 1620146-62-4 (Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione 
• 1620146-63-5 (Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-butylthiazolidine-2,4-dione 
• 1620146-64-6 (Z)-5-(5-allyl-2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzylidene)-3-benzylthiazolidine-2,4-dione 
• 1620146-65-7 (Z)-5-(5-allyl-4-hydroxy-2-methoxybenzylidene)-3-methylthiazolidine-2,4-dione 
• 1620146-66-8 (Z)-5-(5-allyl-4-hydroxy-2-methoxybenzylidene)-3-isopropylthiazolidine-2,4-dione 
• 1620146-67-9 (Z)-5-(5-allyl-4-hydroxy-2-methoxybenzylidene)-3-allylthiazolidine-2,4-dione 
• 1620146-68-0 (Z)-5-(5-allyl-4-hydroxy-2-methoxybenzylidene)-3-(3-methylbut-2-en-1-yl)thiazolidine-2,4-dione 
• 1620146-69-1 (Z)-5-(5-allyl-4-hydroxy-2-methoxybenzylidene)-3-butylthiazolidine-2,4-dione 
• 1620146-70-4 (Z)-5-(5-allyl-4-hydroxy-2-methoxybenzylidene)-3-benzylthiazolidine-2,4-dione 

Relevant academic research and scientific papers

Design, synthesis and docking study of 5-(substituted benzylidene) thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B

A series of novel 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives was designed, and synthesized based on our previous studies. Also their activities were evaluated as competitive inhibitors of protein tyrosine phosphatase 1B (PTP1B). Compounds 6d-6g, 7b, 7c, 7e, 7j, 7k, 7m, 14b and 14e-14f showed potent inhibitory effects against PTP1B, and compound 7e, the most potent among the series, had an IC50 of 4.6 μM. Also a Surflex-Dock docking model of 7e was studied. Compound 7e showed a negative binding energy of -7.35 kcal/mol and a high affinity to PTP1B residues (Gly220, Ala217, Arg221, Asp181, Ser216, Cys215, Phe182, Gln262 and Ile219) in the active sites, indicating that it may stabilize the open form and generate tighter binding to the catalytic sites of PTP1B.

Zinc-catalyzed Williamson ether synthesis in the absence of base

A zinc-catalyzed Williamson ether synthesis is described with microwave heating in the presence of DMF or stirring in an oil-bath using THF as solvent and in the absence of base. Zinc powder was found to be a highly efficient catalyst for the synthesis of aromatic ethers using microwave heating in the presence of N,N-dimethylformamide as well as under stirring in an oil-bath using tetrahydrofuran as solvent without any inorganic base. This method can be used for selective mono-, di- or tri-O-alkylations.