(3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester

Base Information

Chemical Name:(3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester
CAS No.:223437-56-7
Molecular Formula:C₃₅H₄₈O₄Si₂
Molecular Weight:588.935
Hs Code.:

Synonyms:(3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester

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Chemical Property of (3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester

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Technology Process of (3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester

There total 5 articles about (3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 223437-58-9
(3S,4R)-6-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3,4-bis-(dimethyl-p-tolyl-silanyl)-6-oxo-hexanoic acid tert-butyl ester

: 100-51-6,185532-71-2
benzyl alcohol

: 223437-56-7
(3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester

Guidance literature:: With tetrabutoxytitanium; at 75 ℃; for 24h;
DOI:10.1039/a808838a

Reference yield:

: 215110-55-7
(3R,4S)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid

: 223437-56-7
(3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / DCCI / CH₂Cl₂ / 12 h / Ambient temperature

2: BuLi / tetrahydrofuran; hexane / 1.) -40 deg C, 2.) -78 deg C to r.t., 3 h

3: (COCl)2 / dimethylformamide / 2 h / Ambient temperature

4: DMAP / Ambient temperature

5: 87 percent / Ti(OBn)4 / 24 h / 75 °C

With tetrabutoxytitanium; dmap; n-butyllithium; oxalyl dichloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a808838a

Reference yield:

: 159276-68-3
(4S,5R)-4,5-Bis-(dimethyl-p-tolyl-silanyl)-oxepane-2,7-dione

: 223437-56-7
(3S,4R)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-hexanedioic acid benzyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: BuLi / tetrahydrofuran; hexane / 1.) -40 deg C, 2.) -78 deg C to r.t., 3 h

2: (COCl)2 / dimethylformamide / 2 h / Ambient temperature

3: DMAP / Ambient temperature

4: 87 percent / Ti(OBn)4 / 24 h / 75 °C

With tetrabutoxytitanium; dmap; n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/a808838a