<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Base Information

• Chemical Name: <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid
• CAS No.: 128650-87-3
• Molecular Formula: C₁₇H₁₄N₂O₅
• Molecular Weight: 326.309
• Mol file: 128650-87-3.mol

Synonyms:<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Chemical Property of <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

There total 5 articles about <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

Ethyl 2-[1,2,3,4-tetrahydro-3-(4-methoxybenzyl)-2,4-dioxoquinazolin-1-yl]acetate (112732-92-0) → <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid (128650-87-3)

Guidance literature:

With pyridine hydrochloride; at 190 ℃; for 5h;

DOI:10.1016/0223-5234(90)90019-Y

Reference yield:

isatoic anhydride (118-48-9) → <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid (128650-87-3)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 2 h / Heating

2: N-methyl pyrrolidinone / 12 h / 180 °C

3: 1.) sodium hydride / 1.) DMF, 50 deg C, 1 h, 2.) 90 deg C, 7 h

4: 71.5 percent / pyridine hydrochloride / 5 h / 190 °C

With 1-methyl-pyrrolidin-2-one; pyridine hydrochloride; sodium hydride; In ethanol;

DOI:10.1016/0223-5234(90)90019-Y

Reference yield:

4-methoxy-benzylamine (2393-23-9) → <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid (128650-87-3)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 2 h / Heating

2: N-methyl pyrrolidinone / 12 h / 180 °C

3: 1.) sodium hydride / 1.) DMF, 50 deg C, 1 h, 2.) 90 deg C, 7 h

4: 71.5 percent / pyridine hydrochloride / 5 h / 190 °C

With 1-methyl-pyrrolidin-2-one; pyridine hydrochloride; sodium hydride; In ethanol;

DOI:10.1016/0223-5234(90)90019-Y

upstream raw materials:

Ethyl 2-[1,2,3,4-tetrahydro-3-(4-methoxybenzyl)-2,4-dioxoquinazolin-1-yl]acetate

isatoic anhydride

2-amino-N-(4-methoxybenzyl)benzamide

3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

Refernces