<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Base Information

Chemical Name:<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid
CAS No.:128650-87-3
Molecular Formula:C₁₇H₁₄N₂O₅
Molecular Weight:326.309
Hs Code.:

Synonyms:<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Suppliers and Price of <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

There total 5 articles about <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

: 112732-92-0
Ethyl 2-[1,2,3,4-tetrahydro-3-(4-methoxybenzyl)-2,4-dioxoquinazolin-1-yl]acetate

: 128650-87-3
<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Guidance literature:: With pyridine hydrochloride; at 190 ℃; for 5h;
DOI:10.1016/0223-5234(90)90019-Y

Reference yield:

: 118-48-9
isatoic anhydride

: 128650-87-3
<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 2 h / Heating

2: N-methyl pyrrolidinone / 12 h / 180 °C

3: 1.) sodium hydride / 1.) DMF, 50 deg C, 1 h, 2.) 90 deg C, 7 h

4: 71.5 percent / pyridine hydrochloride / 5 h / 190 °C

With 1-methyl-pyrrolidin-2-one; pyridine hydrochloride; sodium hydride; In ethanol;
DOI:10.1016/0223-5234(90)90019-Y

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 128650-87-3
<3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 2 h / Heating

2: N-methyl pyrrolidinone / 12 h / 180 °C

3: 1.) sodium hydride / 1.) DMF, 50 deg C, 1 h, 2.) 90 deg C, 7 h

4: 71.5 percent / pyridine hydrochloride / 5 h / 190 °C

With 1-methyl-pyrrolidin-2-one; pyridine hydrochloride; sodium hydride; In ethanol;
DOI:10.1016/0223-5234(90)90019-Y