5-methyl-2-p-tolylbenzothiophen

Base Information

• Chemical Name: 5-methyl-2-p-tolylbenzothiophen
• CAS No.: 22721-01-3
• Molecular Formula: C₁₆H₁₄S
• Molecular Weight: 238.353
• Mol file: 22721-01-3.mol

Synonyms:5-methyl-2-p-tolylbenzothiophen

Chemical Property of 5-methyl-2-p-tolylbenzothiophen

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-2-p-tolylbenzothiophen

There total 4 articles about 5-methyl-2-p-tolylbenzothiophen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-methylthianaphthene (14315-14-1) + para-bromotoluene (106-38-7) → 5-methyl-2-p-tolylbenzothiophen (22721-01-3)

Guidance literature:

With ISOPROPYLAMIDE; C₂₄H₁₅ClN₂Pd; potassium carbonate; trimethylpyruvic acid; at 150 ℃; for 20h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0040-1707213

Reference yield: 86.0%

5-methylthianaphthene (14315-14-1) + 4-tolyl iodide (624-31-7) → 5-methyl-2-p-tolylbenzothiophen (22721-01-3)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; sodium acetate; palladium diacetate; silver(l) oxide; at 30 ℃; for 16h; regioselective reaction;

DOI:10.1021/jacs.8b05361

Reference yield: 70.0%

6-methylbenzo[b]thiophene (16587-47-6) + toluene (108-88-3,15644-74-3,16713-13-6) → 2-(4-methyl)phenyl-6-methylbenzothiophene (22720-97-4) + 5-methyl-2-p-tolylbenzothiophen (22721-01-3)

Guidance literature:

With aluminium trichloride; for 2h; Yields of byproduct given; Heating;

upstream raw materials:

6-methylbenzo[b]thiophene

toluene

5-methylthianaphthene

4-tolyl iodide

Downstream raw materials:

4-{4-[4-(5-methyl-benzo[b]thiophen-2-yl)-styryl]-phenyl}-2-phenyl-2H-[1,2,3]triazole