2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester

Base Information

• Chemical Name: 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester
• CAS No.: 208251-94-9
• Molecular Formula: C₂₂H₂₂N₂O₅
• Molecular Weight: 394.427

Synonyms:2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester

Chemical Property of 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester

Chemical Property:

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Technology Process of 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester

There total 2 articles about 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,3,3-tetramethylcyclopropane-1-carboxylic acid (15641-58-4) → 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester (208251-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂, DMF / CHCl₃ / 1.58 h / 60 - 65 °C

2: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; chloroform;

DOI:10.1021/jf9710847

Reference yield:

2,2,3,3-tetramethylcyclopropanecarbonyl chloride (24303-61-5) + 2-hydroxy-2-[3-(4-nitrophenoxy)phenyl]acetonitrile (474457-53-9) → 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester (208251-94-9)

Guidance literature:

With pyridine; In dichloromethane; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jf9710847

Reference yield: 69.0%

2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester (208251-94-9) → 2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid [3-(4-amino-phenoxy)-phenyl]-cyano-methyl ester

Guidance literature:

With tin(ll) chloride; In ethanol; at 70 ℃; for 0.583333h;

DOI:10.1021/jf9710847

upstream raw materials:

2,2,3,3-tetramethylcyclopropanecarbonyl chloride

2-hydroxy-2-[3-(4-nitrophenoxy)phenyl]acetonitrile

2,2,3,3-tetramethylcyclopropane-1-carboxylic acid

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