1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

Base Information

Chemical Name:1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one
CAS No.:158010-25-4
Molecular Formula:C₂₇H₄₂O₄
Molecular Weight:430.628
Hs Code.:

Synonyms:1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

Suppliers and Price of 1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

There total 14 articles about 1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 862603-76-7
1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-ol

: 158010-25-4
1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ja0526867

Reference yield:

: 100-39-0
benzyl bromide

: 158010-25-4
1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

Guidance literature:: Multi-step reaction with 11 steps

1: NaH

2: nBu₄NF / tetrahydrofuran

3: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2) CH₂Cl₂, -78 to 0 deg C

4: 1) CuBr*Me₂S / 1) Et₂O, -78 deg C, 2) Et₂O, -78 to 20 deg C

5: AcOH, H₂O / tetrahydrofuran

6: pyridine / 0 °C

7: K₂CO₃ / methanol

8: AcOH / CH₂Cl₂ / Ambient temperature

9: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2) CH₂Cl₂, -78 to 0 deg C

10: CH₂Cl₂; diethyl ether

11: 1) (COCl)2, DMSO, 2) Et₃N / 1) -78 deg C, 2) -78 to 0 deg C

With pyridine; oxalyl dichloride; copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)77159-0

Reference yield:

: [(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-methanol

: 158010-25-4
1-((2S,5R,2'S,5'R)-5'-Benzyloxymethyl-octahydro-[2,2']bifuranyl-5-yl)-undecan-1-one

Guidance literature:: Multi-step reaction with 11 steps

1: NaH

2: nBu₄NF / tetrahydrofuran

3: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2) CH₂Cl₂, -78 to 0 deg C

4: 1) CuBr*Me₂S / 1) Et₂O, -78 deg C, 2) Et₂O, -78 to 20 deg C

5: AcOH, H₂O / tetrahydrofuran

6: pyridine / 0 °C

7: K₂CO₃ / methanol

8: AcOH / CH₂Cl₂ / Ambient temperature

9: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2) CH₂Cl₂, -78 to 0 deg C

10: CH₂Cl₂; diethyl ether

11: 1) (COCl)2, DMSO, 2) Et₃N / 1) -78 deg C, 2) -78 to 0 deg C

With pyridine; oxalyl dichloride; copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)77159-0