(S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

Base Information

Chemical Name:(S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol
CAS No.:914675-35-7
Molecular Formula:C₅₄H₅₇N₂O₆P
Molecular Weight:861.03
Hs Code.:

Synonyms:(S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

Suppliers and Price of (S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

There total 6 articles about (S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 914675-32-4
(S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-1-O-(4,4'-dimethoxytrityl)glycerol

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 914675-35-7
(S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/ejoc.200600168

Reference yield:

: 914675-25-5
(S)-4-(3-bromobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

: 914675-35-7
(S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

Guidance literature:: Multi-step reaction with 4 steps

1: 28 percent / Et₃N; CuI; Pd(PPh₃)2Cl₂ / dimethylformamide; dioxane / 72 h / 80 °C

2: acetic acid; H₂O / 24 h / 20 °C

3: 240 mg / Et₃N / CH₂Cl₂ / 20 °C

4: 57 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N-diisopropylamine tetrazolide; triethylamine; In 1,4-dioxane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1002/ejoc.200600168

Reference yield:

: (R)-3-(3-Biphenyl-4-ylethynyl-benzyloxy)-propane-1,2-diol

: 914675-35-7
(S)-3-O-[3-(biphenyl-4-ylethynyl)phenylmethyl]-2-O-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]-1-O-(4,4'-dimethoxytrityl)glycerol

Guidance literature:: Multi-step reaction with 2 steps

1: 240 mg / Et₃N / CH₂Cl₂ / 20 °C

2: 57 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 24 h / 20 °C

With N,N-diisopropylamine tetrazolide; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.200600168