6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine

Base Information

Chemical Name:6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine
CAS No.:1202034-28-3
Molecular Formula:C₂₄H₂₅BrN₆O
Molecular Weight:493.406
Hs Code.:

Synonyms:6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine

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Chemical Property of 6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine

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Technology Process of 6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine

There total 6 articles about 6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882672-05-1
6-bromo-2-chloroquinazoline

: 1202036-21-2
C₁₆H₂₂N₄O

: 1202034-28-3
6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine

Guidance literature:: In isopropyl alcohol; at 100 ℃; for 16h;

Reference yield:

: 1202036-18-7
1-(3-Bromo-5-nitro-phenyl)-ethanol

: 1202034-28-3
6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1.5 h / 80 °C

2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0 - 20 °C

2.2: 87 h / 50 - 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 48 h / 20 °C / 760.05 Torr / Inert atmosphere of argon

4.1: isopropyl alcohol / 16 h / 100 °C

With hydrogen; sodium carbonate; methanesulfonyl chloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; isopropyl alcohol; 1.1: Suzuki Coupling;

Reference yield:

: 1202036-19-8
C₁₂H₁₃N₃O₃

: 1202034-28-3
6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-morpholinoethyl)phenyl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0 - 20 °C

1.2: 87 h / 50 - 60 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 48 h / 20 °C / 760.05 Torr / Inert atmosphere of argon

3.1: isopropyl alcohol / 16 h / 100 °C

With hydrogen; methanesulfonyl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; isopropyl alcohol;