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6-Bromo-2-chloroquinazoline is a heterocyclic aromatic chemical compound with the molecular formula C8H5BrClN2. It features a quinazoline ring structure with bromine and chlorine substituents, making it a versatile building block in the synthesis of pharmaceuticals and other organic compounds.

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  • 882672-05-1 Structure
  • Basic information

    1. Product Name: 6-Bromo-2-chloroquinazoline
    2. Synonyms: 6-bromo-2-chloroquinazoline;6-BroMo-2-chloroquinazoli...;6-Bromo-2-chloroquizoline
    3. CAS NO:882672-05-1
    4. Molecular Formula: C8H4BrClN2
    5. Molecular Weight: 243.49
    6. EINECS: N/A
    7. Product Categories: CHIRAL CHEMICALS
    8. Mol File: 882672-05-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 240.2 °C at 760 mmHg
    3. Flash Point: 99.1 °C
    4. Appearance: /
    5. Density: 1.762
    6. Vapor Pressure: 0.0596mmHg at 25°C
    7. Refractive Index: 1.691
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    9. Solubility: N/A
    10. PKA: -0.54±0.30(Predicted)
    11. CAS DataBase Reference: 6-Bromo-2-chloroquinazoline(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-Bromo-2-chloroquinazoline(882672-05-1)
    13. EPA Substance Registry System: 6-Bromo-2-chloroquinazoline(882672-05-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 882672-05-1(Hazardous Substances Data)

882672-05-1 Usage

Uses

Used in Pharmaceutical Industry:
6-Bromo-2-chloroquinazoline is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Bromo-2-chloroquinazoline is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its reactivity and potential to form bioactive molecules that can control or eliminate pests and weeds.
Used in Materials Science:
6-Bromo-2-chloroquinazoline is employed in materials science for the development of novel materials with specific properties, such as optoelectronic materials, where its aromatic and halogenated nature can influence the material's electronic and optical characteristics.
Used as a Research Reagent:
6-Bromo-2-chloroquinazoline serves as a valuable research reagent in laboratories, where it is used to study chemical reactions and develop new compounds. Its unique structure allows researchers to explore its reactivity and potential applications in various chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 882672-05-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,2,6,7 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 882672-05:
(8*8)+(7*8)+(6*2)+(5*6)+(4*7)+(3*2)+(2*0)+(1*5)=201
201 % 10 = 1
So 882672-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H4BrClN2/c9-6-1-2-7-5(3-6)4-11-8(10)12-7/h1-4H

882672-05-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Bromo-2-chloroquinazoline

1.2 Other means of identification

Product number -
Other names Quinazoline,6-bromo-2-chloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:882672-05-1 SDS

882672-05-1Relevant articles and documents

Inhibitors of the fibroblast growth factor receptor

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Page/Page column 38; 39, (2017/08/01)

Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of FGFR-4.

Deuterium kinase selective inhibitor

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, (2017/11/30)

The invention relates to a deuterium kinase selective inhibitor and provides a compound shown as formula (I), a stereoisomer, a tautomer or pharmaceutically acceptable salt thereof and the application of the compound used as FGFR4 kinase selective inhibit

IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK

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Page/Page column 49; 50, (2017/04/11)

The invention is directed to substituted imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y1, Y2 and Z are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes, as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt-Jakob Disease, fatal familial insomnia, Gerstmann-Str?ussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR

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Paragraph 0446; 0455; 0456, (2015/05/05)

Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR

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Paragraph 0131; 0132, (2015/07/22)

Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of FGFR-4.

INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR

-

Page/Page column 37; 38, (2014/02/15)

Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.

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