(2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine

Base Information

Chemical Name:(2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine
CAS No.:1220352-24-8
Molecular Formula:C₁₉H₁₈F₃NO₃
Molecular Weight:365.352
Hs Code.:

Synonyms:(2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine

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Chemical Property of (2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine

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Technology Process of (2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine

There total 1 articles about (2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-phenylpropanoyl)-oxazolidine

: 1220352-24-8
(2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-phenylpropanoyl)-oxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With oxygen; triethyl phosphite; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol100211s

Reference yield: 96.0%

: 1220352-24-8
(2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine

: 100-39-0
benzyl bromide

: 1220352-29-3
(2S,4R)-3-[(2R)-2-benzyloxy-3-phenylpropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-3-[(2R)-2-hydroxy-3-phenylpropanoyl]-4-phenyl-1,3-oxazolidine; With sodium hydride; In tetrahydrofuran; Inert atmosphere; Cooling;

benzyl bromide; In tetrahydrofuran; at 20 ℃; optical yield given as %de; Inert atmosphere; Cooling;
DOI:10.1021/ol100211s