(R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide

Base Information

• Chemical Name: (R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide
• CAS No.: 211031-93-5
• Molecular Formula: C₂₇H₃₂N₄O₅S₂
• Molecular Weight: 556.707

Synonyms:(R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide

Chemical Property of (R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide

There total 2 articles about (R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)ethyl]Amino]Ethyl]Phenyl]-4-Cyano-Benzensulfonamide (182251-98-5) → (R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide (211031-93-5)

Guidance literature:

With hydrogen sulfide; triethylamine; In benzene; at 22 ℃;

DOI:10.1016/S0960-894X(00)00390-5

Reference yield:

(R)-N-[2-(4-aminophenyl)ethyl]-2-hydroxy-2-(3-pyridyl)ethylcarbamic acid 1,1-dimethylethyl ester (173901-05-8) → (R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide (211031-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂

2: H₂S; Et₃N / benzene / 22 °C

With pyridine; hydrogen sulfide; triethylamine; In dichloromethane; benzene; 1: sulfonylation / 2: Addition;

DOI:10.1016/S0960-894X(00)00390-5

Reference yield:

(R)-N-[4-[2-[N-(1,1-dimethylethoxycarbonyl)-N-[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-(aminothiocarbonyl)benzenesulfonamide (211031-93-5) + 2-chloro-1-(pyridin-2-yl)ethanone (55484-10-1) → (2-hydroxy-2-pyridin-3-yl-ethyl)-(2-{4-[4-(4-pyridin-2-yl-thiazol-2-yl)-benzenesulfonylamino]-phenyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:

In ethanol; at 80 ℃;

DOI:10.1016/S0960-894X(00)00390-5

upstream raw materials:

(R)-N-[4-[2-[N-(1,1-Dimethylethoxycarbonyl)-N-[2-Hydroxy-2-(Pyridin-3-Yl)ethyl]Amino]Ethyl]Phenyl]-4-Cyano-Benzensulfonamide

(R)-N-[2-(4-aminophenyl)ethyl]-2-hydroxy-2-(3-pyridyl)ethylcarbamic acid 1,1-dimethylethyl ester

Downstream raw materials:

[2-(4-{4-[4-(2,4-difluoro-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

[2-(4-{4-[4-(3,4-difluoro-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

(2-hydroxy-2-pyridin-3-yl-ethyl)-[2-(4-{4-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-ethyl]-carbamic acid tert-butyl ester

(2-hydroxy-2-pyridin-3-yl-ethyl)-[2-(4-{4-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-ethyl]-carbamic acid tert-butyl ester

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