Technology Process of tert-butyl 4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(6-(morpholinomethyl)pyridin-3-yl)phenyl)(methyl)amino)piperidine-1-carboxylate
There total 10 articles about tert-butyl 4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(6-(morpholinomethyl)pyridin-3-yl)phenyl)(methyl)amino)piperidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
morpholine; tert-butyl 4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl) carbamoyl)-5-(6-formylpyridin-3-yl)-2-methylphenyl)(methyl)amino) piperidine-1-carboxylate;
With
acetic acid;
In
methanol;
at 20 ℃;
for 4h;
With
methanol; sodium cyanoborohydride;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C
2.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C
3.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C
3.2: 0 - 20 °C
4.1: caesium carbonate / acetonitrile / 20 h / 80 °C
5.1: sodium hydroxide; water / methanol / 1 h / 60 °C
5.2: pH 6
5.3: pH 4
6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C
7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
8.1: acetic acid / methanol / 4 h / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
7.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C
2.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C
2.2: 0 - 20 °C
3.1: caesium carbonate / acetonitrile / 20 h / 80 °C
4.1: sodium hydroxide; water / methanol / 1 h / 60 °C
4.2: pH 6
4.3: pH 4
5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C
6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
7.1: acetic acid / methanol / 4 h / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; water; dimethyl sulfoxide; acetonitrile;
6.1: Suzuki Coupling;
