4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Base Information

Chemical Name:4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid
CAS No.:1335465-88-7
Molecular Formula:C₂₁H₁₆Cl₂FN₃O₅
Molecular Weight:480.28
Hs Code.:

Synonyms:4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

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Chemical Property of 4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

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Technology Process of 4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

There total 10 articles about 4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1335465-80-9
ethyl 4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

: 1335465-88-7
4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1002/jlcr.1901

Reference yield:

: 132838-18-7
1-(2-fluoroethoxy)-2-nitrobenzene

: 1335465-88-7
4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 0 °C / 750.08 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

3: dichloromethane / 0 - 20 °C / Inert atmosphere

4: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

5: sodium hydroxide / tetrahydrofuran; water / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium ethanolate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1002/jlcr.1901

Reference yield:

: 103855-01-2
ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate

: 1335465-88-7
4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: polyphosphoric acid / 0.17 h / 70 - 130 °C

2.1: trichlorophosphate / 20 °C / Inert atmosphere

2.2: 8 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 1.5 h / Inert atmosphere

5.1: dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: sodium ethanolate / ethanol / 1 h / 20 °C / Inert atmosphere

7.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

With sodium ethanolate; sodium tris(acetoxy)borohydride; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; 1.1: Fischer indole synthesis / 2.2: Vilsmeier formylation;
DOI:10.1002/jlcr.1901