Technology Process of C23H28NPO8
There total 5 articles about C23H28NPO8 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4-(N-benzyloxycarbonyl-N-methylamino)phenyl)phosphinic acid; dimethyl 2-methylenepentanedioate;
With
N,O-bis-(trimethylsilyl)-acetamide;
In
dichloromethane;
at 20 ℃;
for 24h;
With
hydrogenchloride;
In
dichloromethane;
for 0.5h;
Further stages.;
DOI:10.1021/jo0707840
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: anilinium hypophosphite; triethylamine / Pd(PPh3)4 / acetonitrile / 24 h / Heating
2.1: N,O-bis(trimethylsilyl)acetamide / CH2Cl2 / 24 h / 20 °C
2.2: aq. HCl / CH2Cl2 / 0.5 h
With
N,O-bis-(trimethylsilyl)-acetamide; anilinium hypophosphorous salt; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane; acetonitrile;
DOI:10.1021/jo0707840
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 92 percent / sodium hydride / various solvent(s); tetrahydrofuran / 5 h / 20 °C
2.1: anilinium hypophosphite; triethylamine / Pd(PPh3)4 / acetonitrile / 24 h / Heating
3.1: N,O-bis(trimethylsilyl)acetamide / CH2Cl2 / 24 h / 20 °C
3.2: aq. HCl / CH2Cl2 / 0.5 h
With
N,O-bis-(trimethylsilyl)-acetamide; anilinium hypophosphorous salt; sodium hydride; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo0707840
