N⁴-(N-carbobenzoxy-L-threonyl)-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

Base Information

• Chemical Name: N⁴-(N-carbobenzoxy-L-threonyl)-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine
• CAS No.: 82247-45-8
• Molecular Formula: C₃₇H₄₈N₄O₁₀
• Molecular Weight: 708.809
• Mol file: 82247-45-8.mol

Synonyms:N⁴-(N-carbobenzoxy-L-threonyl)-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

Chemical Property of N⁴-(N-carbobenzoxy-L-threonyl)-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(N-carbobenzoxy-L-threonyl)-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

There total 1 articles about N⁴-(N-carbobenzoxy-L-threonyl)-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-treonine (19728-63-3) + N1,N8-Bis(2,3-bis(methyloxy)benzoyl)spermidine (78217-75-1) → N4-(N-carbobenzoxy-L-threonyl)-N1,N8-bis(2,3-dimethoxybenzoyl)spermidine (82247-45-8)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; Multistep reaction; 1) THF, 0 deg C;

DOI:10.1021/ja00380a032

Reference yield:

N4-(N-carbobenzoxy-L-threonyl)-N1,N8-bis(2,3-dimethoxybenzoyl)spermidine (82247-45-8) → N4-L-threonyl-N1,N8-bis(2,3-dimethoxybenzoyl)spermidine (89675-85-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dichloride; In methanol; for 24h;

DOI:10.1021/ja00380a032

Reference yield:

N4-(N-carbobenzoxy-L-threonyl)-N1,N8-bis(2,3-dimethoxybenzoyl)spermidine (82247-45-8) → N1,N8-bis(2,3-dihydroxybenzoyl)-M4-(L-threonyl)spermidine hydrobromide (82247-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen, HCl / PdCl₂ / methanol / 24 h

2: 1.) BBr₃, 2.) H₂O / 1) CH₂Cl_2. 0 deg C, 6 h; 2) methanol

With hydrogenchloride; water; hydrogen; boron tribromide; palladium dichloride; In methanol;

DOI:10.1021/ja00380a032

upstream raw materials:

N-benzyloxycarbonyl-L-treonine

N¹,N⁸-Bis(2,3-bis(methyloxy)benzoyl)spermidine

Downstream raw materials:

N⁴-L-threonyl-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine

N¹,N⁸-bis(2,3-dihydroxybenzoyl)-M⁴-(L-threonyl)spermidine hydrobromide

parabactin