Technology Process of benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-((methoxymethoxy)methyl)but-3-en-1-yl)carbamate
There total 10 articles about benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-((methoxymethoxy)methyl)but-3-en-1-yl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 12h;
Cooling with ice;
DOI:10.1016/j.tetasy.2011.07.009
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; toluene; mineral oil / 1 h / 20 °C / Cooling with ice
2.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / -10 - 20 °C
2.2: 2 h / 0 - 20 °C
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 5 h / 20 °C / Cooling with ice
4.1: triethylamine / dichloromethane / 3 h / 20 °C
5.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / -78 °C
6.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Cooling with ice
With
dmap; sodium tetrahydroborate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; cerium(III) chloride heptahydrate; dimethylsulfide borane complex; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil;
DOI:10.1016/j.tetasy.2011.07.009
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: zinc / tetrahydrofuran / -15 - 20 °C
2.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C
3.1: sodium hydride / tetrahydrofuran; toluene; mineral oil / 1 h / 20 °C / Cooling with ice
4.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / -10 - 20 °C
4.2: 2 h / 0 - 20 °C
5.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 5 h / 20 °C / Cooling with ice
6.1: triethylamine / dichloromethane / 3 h / 20 °C
7.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / -78 °C
8.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Cooling with ice
With
1H-imidazole; dmap; sodium tetrahydroborate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; cerium(III) chloride heptahydrate; dimethylsulfide borane complex; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil;
DOI:10.1016/j.tetasy.2011.07.009
