4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

Base Information

Chemical Name:4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester
CAS No.:99272-75-0
Molecular Formula:C₄₆H₄₇ClN₃O₁₄P
Molecular Weight:932.318
Hs Code.:

4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

Synonyms:4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

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Chemical Property of 4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

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Technology Process of 4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

There total 9 articles about 4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 99272-71-6
4-[(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester

: 99272-75-0
4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

Guidance literature:: With trichloroacetic acid; In chloroform; at 0 ℃;

Reference yield:

: 98-01-1
furfural

: 99272-75-0
4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / 2.5 h / Heating

2: 0.79 mol / HCl / reflux, 3 h; RT, overnight

3: 72.9 percent / benzenesulfonic acid / 3 h / Heating

4: 73.8 percent / benzenesulfonic acid / various solvent(s) / 10 h / 168 °C

5: 76 percent / benzenesulfonic acid / dioxane / 1 h / Ambient temperature

6: 87 percent / pyridine / 1.33 h / Ambient temperature

7: 2.) H₂O / 1.) pyridine, acetonitrile, 20 deg C, 110 min, 2.) 30 min

8: 2.) 1-(mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 1.) pyridine, 2.) pyridine, RT, 65 min

9: 74 percent / 2,2,2-trichloroacetic acid / CHCl₃ / 0 °C

With hydrogenchloride; water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; benzenesulfonic acid; trichloroacetic acid; In 1,4-dioxane; pyridine; chloroform;

Reference yield:

: 22634-92-0
4-oxo-heptanedioic acid dimethyl ester

: 99272-75-0
4-{(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 72.9 percent / benzenesulfonic acid / 3 h / Heating

2: 73.8 percent / benzenesulfonic acid / various solvent(s) / 10 h / 168 °C

3: 76 percent / benzenesulfonic acid / dioxane / 1 h / Ambient temperature

4: 87 percent / pyridine / 1.33 h / Ambient temperature

5: 2.) H₂O / 1.) pyridine, acetonitrile, 20 deg C, 110 min, 2.) 30 min

6: 2.) 1-(mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 1.) pyridine, 2.) pyridine, RT, 65 min

7: 74 percent / 2,2,2-trichloroacetic acid / CHCl₃ / 0 °C

With water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; benzenesulfonic acid; trichloroacetic acid; In 1,4-dioxane; pyridine; chloroform;