methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

Base Information

Chemical Name:methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate
CAS No.:1369917-75-8
Molecular Formula:C₃₂H₅₁NO₅Si
Molecular Weight:557.846
Hs Code.:

methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

Synonyms:methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

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Chemical Property of methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

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Technology Process of methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

There total 13 articles about methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1369917-69-0
methyl 4-[1-(2-iodoethyl)cyclopropyl]butanoate

: 1369917-65-6
(5R)-5-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-2-pyrrolidinone

: 1369917-75-8
methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

Guidance literature:: (5R)-5-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-2-pyrrolidinone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;

methyl 4-[1-(2-iodoethyl)cyclopropyl]butanoate; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; Inert atmosphere;
DOI:10.1248/cpb.59.1494

Reference yield:

: 1369918-00-2
C₁₁H₁₈O₄

: 1369917-75-8
methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / methanol / 17 h / 20 °C / Inert atmosphere

2.1: diethylzinc / hexane; dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole; iodine; triphenylphosphine / benzene / 0.5 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

4.2: 50 °C / Inert atmosphere

With 1H-imidazole; iodine; diethylzinc; sodium hydride; potassium carbonate; triphenylphosphine; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil; benzene; 2.1: Simmons-Smith reaction;
DOI:10.1248/cpb.59.1494

Reference yield:

: 1369918-02-4
C₁₀H₁₈O₃

: 1369917-75-8
methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / benzene / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

2.2: 50 °C / Inert atmosphere

With 1H-imidazole; iodine; sodium hydride; triphenylphosphine; In N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1248/cpb.59.1494