N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide

Base Information

Chemical Name:N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide
CAS No.:1607465-31-5
Molecular Formula:C₂₄H₂₀N₈O₂
Molecular Weight:452.475
Hs Code.:

Synonyms:N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide

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Chemical Property of N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide

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Technology Process of N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide

There total 5 articles about N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1607465-30-4
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-cyanobenzamide

: 1607465-31-5
N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In ethanol; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1607465-42-8
2-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isoindoline-1,3-dione

: 1607465-31-5
N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 5 h / 20 °C / Reflux

2.1: triethylamine / dichloromethane / 0.33 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: sodium hydroxide; dihydrogen peroxide / ethanol / 12 h / 0 - 20 °C

With dihydrogen peroxide; hydrazine hydrate; triethylamine; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1607465-43-9
(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methanamine

: 1607465-31-5
N'-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isophthalamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.33 h / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: sodium hydroxide; dihydrogen peroxide / ethanol / 12 h / 0 - 20 °C

With dihydrogen peroxide; triethylamine; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2014.03.022