4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Base Information

Chemical Name:4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide
CAS No.:1333144-84-5
Molecular Formula:C₂₁H₂₂ClNO₄S
Molecular Weight:419.929
Hs Code.:

Synonyms:4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

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Technology Process of 4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

There total 9 articles about 4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1333144-79-8
4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

: 1333144-84-5
4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: With hydrogenchloride; In water; acetone; at 20 ℃; for 13h;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-57-2
3-(2-((triisopropylsilyl)oxy)ethyl)benzaldehyde

: 1333144-84-5
4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / Reflux

2.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

3.2: -78 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: hydrogenchloride / water; acetone / 13 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetone; toluene; acetonitrile; 5.1: Mitsunobu reaction;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-59-4
(3-(iodomethyl)phenethoxy)triisopropylsilane

: 1333144-84-5
4-chloro-N-(3-((4-hydroxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

1.2: -78 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: hydrogenchloride / water; acetone / 13 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; water; acetone; toluene; 3.1: Mitsunobu reaction;
DOI:10.1021/jm200980u