4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Base Information

Chemical Name:4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide
CAS No.:1333144-79-8
Molecular Formula:C₂₅H₃₀ClNO₄S
Molecular Weight:476.036
Hs Code.:

Synonyms:4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

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Chemical Property of 4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

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Technology Process of 4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

There total 9 articles about 4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1333144-75-4
tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

: 1333144-79-8
4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-57-2
3-(2-((triisopropylsilyl)oxy)ethyl)benzaldehyde

: 1333144-79-8
4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / Reflux

2.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

3.2: -78 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene; acetonitrile; 5.1: Mitsunobu reaction;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-58-3
3-(2-((triisopropylsilyl)oxy)ethyl)phenylmethanol

: 1333144-79-8
4-chloro-N-(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

2.2: -78 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; acetonitrile; 4.1: Mitsunobu reaction;
DOI:10.1021/jm200980u