(2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Base Information

Chemical Name:(2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine
CAS No.:1220352-31-7
Molecular Formula:C₂₆H₂₆F₃NO₃
Molecular Weight:457.493
Hs Code.:

Synonyms:(2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

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Chemical Property of (2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

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Technology Process of (2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

There total 1 articles about (2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220352-29-3
(2S,4R)-3-[(2R)-2-benzyloxy-3-phenylpropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

: 1220352-31-7
(2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-3-[(2R)-2-benzyloxy-3-phenylpropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine; With lithium aluminium tetrahydride; In diethyl ether; Inert atmosphere; Cooling;

With water; sodium hydroxide; In diethyl ether; Inert atmosphere;
DOI:10.1021/ol100211s

Reference yield:

: 1220352-31-7
(2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

: 182937-63-9
(R)-2-(benzyloxy)-3-phenylpropanoic acid

: 203176-56-1
(2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine; With acetic acid; In chloroform;

With sodium dihydrogenphosphate; 2-methyl-but-2-ene; water; sodium formate; In tert-butyl alcohol; at 20 ℃; for 1.5h;

With hydrogenchloride; In water; pH=2;
DOI:10.1021/ol100211s

Reference yield:

: 1220352-31-7
(2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

: 123394-77-4
(R)-2-(benzyloxy)-1-hydroxy-3-phenylpropane

: 203176-56-1
(2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine; With acetic acid; In chloroform;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1.5h;

With water; In methanol;
DOI:10.1021/ol100211s