N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine

Base Information

Chemical Name:N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine
CAS No.:359865-12-6
Molecular Formula:C₃₃H₃₀INO₃
Molecular Weight:615.511
Hs Code.:

Synonyms:N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine

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Technology Process of N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine

There total 11 articles about N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 359865-11-5
4α-N-9-phenylfluoren-9-ylamino-3α-acetoxy-5-p-methoxyphenyl-1-pentene

: 359865-12-6
N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine

Guidance literature:: With iodine; In tetrahydrofuran; diethyl ether; sodium hydrogencarbonate; at 20 ℃; for 3h;

Reference yield:

: 359865-08-0
3-p-methoxyphenyl-2α-N-9-phenylfluoren-9-ylamino-1-propanal

: 359865-12-6
N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 0.5 h / -40 °C

2: 91 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 °C

3: 91 percent / BH₃*SMe₂ / toluene / 0.5 h / -78 °C

4: 96 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

5: 90 percent / iodine; NaHCO₃ / tetrahydrofuran; diethyl ether / 36 h / 20 °C

With dmap; oxalyl dichloride; dimethylsulfide borane complex; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 2: Swern oxidation;
DOI:10.1021/jo050079w

Reference yield:

: 359865-10-4
4α-N-9-phenylfluoren-9-ylamino-3α-hydroxy-5-p-methoxyphenyl-1-pentene

: 359865-12-6
N-9-phenylfluoren-9-ylamino-3α-acetoxy-4α-iodo-2α-(p-methoxybenzyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

2: 90 percent / iodine; NaHCO₃ / tetrahydrofuran; diethyl ether / 36 h / 20 °C

With dmap; iodine; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo050079w