Technology Process of 6-tert-butyl-2-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)isoindolin-1-one
There total 4 articles about 6-tert-butyl-2-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)isoindolin-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3-bromo-2-methylphenyl)-6-tert-butylisoindolin-1-one; bis(pinacol)diborane;
With
potassium acetate;
In
1,4-dioxane;
for 0.5h;
Inert atmosphere;
With
XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane;
at 105 ℃;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 20 °C / Inert atmosphere
2.1: pentane; tetrahydrofuran / 0.5 h / -78 - 45 °C / Inert atmosphere
3.1: hydrogenchloride; trifluoroacetic acid / Reflux
3.2: pH 7.5
4.1: caesium carbonate; N,N-dimethylethylenediamine / 1,4-dioxane / 16 h / 105 °C / Inert atmosphere; Reflux
5.1: potassium acetate / 1,4-dioxane / 0.5 h / Inert atmosphere
5.2: 3 h / 105 °C / Reflux
With
hydrogenchloride; potassium acetate; caesium carbonate; N,N-dimethylethylenediamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
dmap;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; pentane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; trifluoroacetic acid / Reflux
1.2: pH 7.5
2.1: caesium carbonate; N,N-dimethylethylenediamine / 1,4-dioxane / 16 h / 105 °C / Inert atmosphere; Reflux
3.1: potassium acetate / 1,4-dioxane / 0.5 h / Inert atmosphere
3.2: 3 h / 105 °C / Reflux
With
hydrogenchloride; potassium acetate; caesium carbonate; N,N-dimethylethylenediamine; trifluoroacetic acid;
In
1,4-dioxane;
