1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

Base Information

Chemical Name:1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol
CAS No.:942914-40-1
Molecular Formula:C₅₉H₁₀₉NO₂₀P₂
Molecular Weight:1214.46
Hs Code.:

Synonyms:1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

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Chemical Property of 1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

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Technology Process of 1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

There total 4 articles about 1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 214422-50-1
N,N-diisopropyl-O-cyanoethyl-O-(di-oleoyl-sn-(2S)-glycerol)phosphonamidite

: 1D-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

: 942914-40-1
1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

Guidance literature:: N,N-diisopropyl-O-cyanoethyl-O-(di-oleoyl-sn-(2S)-glycerol)phosphonamidite; 1D-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol; With 1H-tetrazole; In dichloromethane; at 20 ℃; for 24h;

With tert.-butylhydroperoxide; In dichloromethane; for 1h; Further stages.;
DOI:10.1021/ja070195b

Reference yield:

: 1D-1-O-(tert-butyldiphenylsilyl)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

: 942914-40-1
1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / TBAF*3H₂O / tetrahydrofuran / 4 h / 20 °C

2.1: 1H-tetrazole / CH₂Cl₂ / 24 h / 20 °C

2.2: 45 percent / t-BuOOH / CH₂Cl₂ / 1 h

With 1H-tetrazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja070195b

Reference yield:

: 496921-99-4
1D-1-O-(tert-butyldiphenylsilyl)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

: 942914-40-1
1D-O-(1,2-di-O-oleoyl-sn-glycerol-3-O-(cyanoethyl)phospho)-5-(dimethyl methylenephosphonate)-2,3,4,6-O-tetrakis(methoxymethylene)-myo-inositol

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

1.2: 86 percent / tetrahydrofuran / 12 h / 20 °C

2.1: 96 percent / TBAF*3H₂O / tetrahydrofuran / 4 h / 20 °C

3.1: 1H-tetrazole / CH₂Cl₂ / 24 h / 20 °C

3.2: 45 percent / t-BuOOH / CH₂Cl₂ / 1 h

With 1H-tetrazole; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja070195b