(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

Base Information

Chemical Name:(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine
CAS No.:847990-69-6
Molecular Formula:C₂₈H₂₈ClF₃N₂O
Molecular Weight:500.991
Hs Code.:

Synonyms:(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

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Chemical Property of (2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

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Technology Process of (2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

There total 3 articles about (2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 609772-13-6
{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[(2S)-2-phenylpropyl]amine

: 4-(3-bromopropyloxy)indole

: 847990-69-6
(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 89 ℃; for 12h; Product distribution / selectivity;

Reference yield:

: 17596-79-1
(2S)-2-phenyl-1-propanamine

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 847990-69-6
(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 1.5 h

2: potassium carbonate; sodium iodide / acetonitrile / 12 h / 89 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; sodium iodide; In dichloromethane; acetonitrile;

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 847990-69-6
(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: PS-triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

2: potassium carbonate; sodium iodide / acetonitrile / 12 h / 89 °C

With PS-triphenylphosphine; di-isopropyl azodicarboxylate; potassium carbonate; sodium iodide; In tetrahydrofuran; acetonitrile;