methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

Base Information

Chemical Name:methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate
CAS No.:1002102-01-3
Molecular Formula:C₂₁H₂₀N₂O₃
Molecular Weight:348.401
Hs Code.:

Synonyms:methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

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Chemical Property of methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

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Technology Process of methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

There total 1 articles about methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1002101-93-0
1-phenyl-5-(p-tolyl)-1H-pyrazole-3-carbaldehyde

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1002102-01-3
methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; at 20 ℃; for 0.5h;
DOI:10.1021/ol303109m

Reference yield: 86.0%

: 1002102-01-3
methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

: 75-36-5
acetyl chloride

: 1415989-24-0
methyl 2-(acetoxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1021/ol303109m

Reference yield:

: 1002102-01-3
methyl 2-(hydroxy(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)methyl)acrylate

: 1415989-37-5
(E)-methyl 2-(aminomethyl)-3-(1-phenyl-5-(4-methylphenyl)-1H-pyrazol-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 3 h / 0 - 20 °C

2: methanol; ammonia / 1 h / 20 °C

With pyridine; methanol; ammonia; In dichloromethane;
DOI:10.1021/ol303109m