10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere

Base Information

Chemical Name:10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere
CAS No.:160239-16-7
Molecular Formula:C₄₅H₆₁NO₁₅
Molecular Weight:855.977
Hs Code.:

Synonyms:10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere

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Chemical Property of 10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere

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Technology Process of 10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere

There total 4 articles about 10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 160239-15-6
10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere

: 160239-16-7
10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere

Guidance literature:: With pyridine hydrogenfluoride; In pyridine; for 3h;
DOI:10.1021/jm00046a018

Reference yield:

: 115437-21-3
7-(triethylsilyl)baccatin III

: 160239-16-7
10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / H₂ / 3percent Pt/C / ethyl acetate / 12 h / 1551.4 Torr

2: 78 percent / NaH / tetrahydrofuran / 1.5 h / 25 - 35 °C

3: 84 percent / pyridinium hydrofluoride / pyridine / 3 h

With hydrogen; sodium hydride; pyridine hydrogenfluoride; platinum on activated charcoal; In tetrahydrofuran; pyridine; ethyl acetate;
DOI:10.1021/jm00046a018

Reference yield:

: 152448-63-0
2-debenzoyl-2-cyclohexanecarbonyl-7-triethylsilylbaccatin III

: 160239-16-7
10-O-acetyl-2-O-(cyclohexylcarbonyl)-2-debenzoyltaxotere

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / LiHMDS / tetrahydrofuran / 0.33 h / -40 °C

2: 98 percent / TBAF, AcOH / tetrahydrofuran / 36 h

With tetrabutyl ammonium fluoride; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm9606711