10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere

Base Information

Chemical Name:10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere
CAS No.:160239-15-6
Molecular Formula:C₅₇H₈₉NO₁₅Si₂
Molecular Weight:1084.5
Hs Code.:

Synonyms:10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere

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Chemical Property of 10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere

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Technology Process of 10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere

There total 2 articles about 10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 152089-13-9
(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-oxo-4-phenyl-azetidine-1-carboxylic acid tert-butyl ester

: 152448-63-0
2-debenzoyl-2-cyclohexanecarbonyl-7-triethylsilylbaccatin III

: 160239-15-6
10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 25 - 35 ℃; for 1.5h;
DOI:10.1021/jm00046a018

Reference yield:

: 115437-21-3
7-(triethylsilyl)baccatin III

: 160239-15-6
10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂ / 3percent Pt/C / ethyl acetate / 12 h / 1551.4 Torr

2: 78 percent / NaH / tetrahydrofuran / 1.5 h / 25 - 35 °C

With hydrogen; sodium hydride; platinum on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm00046a018