(2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one

Base Information

• Chemical Name: (2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one
• CAS No.: 699432-69-4
• Molecular Formula: C₂₀H₃₀N₂O₂
• Molecular Weight: 330.47
• Mol file: 699432-69-4.mol

Synonyms:(2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one

Chemical Property of (2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one

There total 1 articles about (2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-(tert-butyl)-3-methylimidazolidin-4-one (101143-56-0) → (2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one (699432-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / methyltrioxorhenium; urea-hydrogen peroxide / methanol / 24 h / 0 - 20 °C

2: 91 percent / 1,2-dichloro-ethane / 5 h / Heating

With urea-hydrogen peroxide; methyltrioxorhenium(VII); In methanol; 1,2-dichloro-ethane;

DOI:10.1021/ol049505a

Reference yield: 86.0%

acetic anhydride (108-24-7) + acetic acid (64-19-7,77671-22-8) + (2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one (699432-69-4) → acetic acid 2-(3-acetyl-2-tert-butyl-1-methyl-5-oxo-imidazolidin-4-yl)-1-(4-tert-butyl-phenyl)-ethyl ester (699432-83-2)

Guidance literature:

With zinc; for 20h;

DOI:10.1021/ol049505a

Reference yield:

(2S,3aS,6S)-6-tert-butyl-2-(4'-tert-butylphenyl)-5-methyl-tetrahydroimidazo[1,5-b]isoxazol-4-one (699432-69-4) → (2S,4S)-2-amino-4-hydroxy-4-p-tert-butylphenylbutanoic acid lactone hydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Zn / 20 h

2: 96 percent / K₂CO₃ / methanol / 1.5 h / Heating

3: 99 percent / aq. HCl / tetrahydrofuran / Heating

With hydrogenchloride; potassium carbonate; zinc; In tetrahydrofuran; methanol;

DOI:10.1021/ol049505a

upstream raw materials:

(2R)-2-(tert-butyl)-3-methylimidazolidin-4-one

Downstream raw materials:

acetic acid 2-(3-acetyl-2-tert-butyl-1-methyl-5-oxo-imidazolidin-4-yl)-1-(4-tert-butyl-phenyl)-ethyl ester

(2R,5S,2'S)-2-tert-butyl-5-[2'-(4''-tert-butylphenyl)-2'-hydroxyethyl]-3-methylimidazolidin-4-one